About Nodwell Lab
About Nodwell Lab
The lab is a lively community of 10-12 scientists pursuing projects that all touch on the chemical genetics of bacteria. Most of the people in the group have undergraduate degrees in microbiology, biochemistry or molecular genetics, often with a strong background in chemistry and computer science.
There is really no technology or model system that is off-limits.
We are interested in how bacteria produce and/or respond to biologically active small molecules and we will explore any technology needed to answer these questions.
We routinely purify and characterize biologically-produced small molecules using HPLC and LC/MS. In some cases we use transcriptome sequencing to identify stress responses induced by bioactive compounds. We isolate resistant mutants and use genome sequencing to identify the sequence changes that confer resistance.
Key people in the group include Dr. Sheila Pimentel-Elardo, a Senior Research Associate and Dr. Jing Li, Senior Technician, who largely run the day-to-day operation of the group in addition to pursuing their own research.
In addition, there are usually 7 – 9 graduate students and postdoctoral fellows in the lab.
We have a weekly lab meeting where people present their own work, brain storming around experiments and publication. In addition, everyone has an informal, monthly meeting with Justin to help unstick projects that have hit road blocks and to chart the most fruitful course for each of the research endeavours we are interested in.
We also work with collaborators pursuing molecules that interact with fungal microbes like Candida and Cryptococcus, intestinal pathogens, bacteriophages, the round worm C. elegans, and the Drosophila fruit fly.
University of Toronto at MaRS Discovery District
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